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psn1 tumor model  (Shanghai Model Organisms Center)

 
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    Shanghai Model Organisms Center psn1 tumor model
    IC 50 values of PR00012 and NMS-P937 against human pancreatic cancer cell lines.
    Psn1 Tumor Model, supplied by Shanghai Model Organisms Center, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/psn1+tumor+model/psn1+tumor+model/pmc11968394-154-6-40
    Average 90 stars, based on 1 article reviews
    psn1 tumor model - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "The effect of deuterated PLK1 inhibitor on its safety and efficacy in vivo"

    Article Title: The effect of deuterated PLK1 inhibitor on its safety and efficacy in vivo

    Journal: Frontiers in Oncology

    doi: 10.3389/fonc.2025.1510052

    IC 50 values of PR00012 and NMS-P937 against human pancreatic cancer cell lines.
    Figure Legend Snippet: IC 50 values of PR00012 and NMS-P937 against human pancreatic cancer cell lines.

    Techniques Used:

    Pharmacokinetics of PR00012 and NMS-P937 in PSN1 tumor CDX model using M-NSG mice. The tumor-bearing M-NSG mice were dosed with PR00012 or NMS-P937 at 60 mg/kg, 30 mg/kg, or 15 mg/kg. Blood samples were collected at seven time points. Compound concentration in the blood were determined and theT1/2 was calculated.
    Figure Legend Snippet: Pharmacokinetics of PR00012 and NMS-P937 in PSN1 tumor CDX model using M-NSG mice. The tumor-bearing M-NSG mice were dosed with PR00012 or NMS-P937 at 60 mg/kg, 30 mg/kg, or 15 mg/kg. Blood samples were collected at seven time points. Compound concentration in the blood were determined and theT1/2 was calculated.

    Techniques Used: Drug discovery, Concentration Assay

    Related Articles

    In Vivo:

    Article Title: The effect of deuterated PLK1 inhibitor on its safety and efficacy in vivo
    Article Snippet: .. For in vivo PK/PD studies, a PSN1 tumor model was established in female M-NSG (NOD.Cg- Prkdc scid Il2rg em1Smoc ) mice, which are severely immunodeficient mice lacking the interleukin 2 receptor gamma chain on a NOD.Cg- Prkdc scid background, at Shanghai Model Organisms (Shanghai, China). ..



    Similar Products

    psn1 tumor model  (Shanghai Model Organisms Center)
    90
    Shanghai Model Organisms Center psn1 tumor model
    IC 50 values of PR00012 and NMS-P937 against human pancreatic cancer cell lines.
    Psn1 Tumor Model, supplied by Shanghai Model Organisms Center, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/psn1+tumor+model/psn1+tumor+model/pmc11968394-154-6-40
    Average 90 stars, based on 1 article reviews
    psn1 tumor model - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    IC 50 values of PR00012 and NMS-P937 against human pancreatic cancer cell lines.

    Journal: Frontiers in Oncology

    Article Title: The effect of deuterated PLK1 inhibitor on its safety and efficacy in vivo

    doi: 10.3389/fonc.2025.1510052

    Figure Lengend Snippet: IC 50 values of PR00012 and NMS-P937 against human pancreatic cancer cell lines.

    Article Snippet: For in vivo PK/PD studies, a PSN1 tumor model was established in female M-NSG (NOD.Cg- Prkdc scid Il2rg em1Smoc ) mice, which are severely immunodeficient mice lacking the interleukin 2 receptor gamma chain on a NOD.Cg- Prkdc scid background, at Shanghai Model Organisms (Shanghai, China).

    Techniques:

    Pharmacokinetics of PR00012 and NMS-P937 in PSN1 tumor CDX model using M-NSG mice. The tumor-bearing M-NSG mice were dosed with PR00012 or NMS-P937 at 60 mg/kg, 30 mg/kg, or 15 mg/kg. Blood samples were collected at seven time points. Compound concentration in the blood were determined and theT1/2 was calculated.

    Journal: Frontiers in Oncology

    Article Title: The effect of deuterated PLK1 inhibitor on its safety and efficacy in vivo

    doi: 10.3389/fonc.2025.1510052

    Figure Lengend Snippet: Pharmacokinetics of PR00012 and NMS-P937 in PSN1 tumor CDX model using M-NSG mice. The tumor-bearing M-NSG mice were dosed with PR00012 or NMS-P937 at 60 mg/kg, 30 mg/kg, or 15 mg/kg. Blood samples were collected at seven time points. Compound concentration in the blood were determined and theT1/2 was calculated.

    Article Snippet: For in vivo PK/PD studies, a PSN1 tumor model was established in female M-NSG (NOD.Cg- Prkdc scid Il2rg em1Smoc ) mice, which are severely immunodeficient mice lacking the interleukin 2 receptor gamma chain on a NOD.Cg- Prkdc scid background, at Shanghai Model Organisms (Shanghai, China).

    Techniques: Drug discovery, Concentration Assay